VISUALING THE MOLECULES OF LIFE
Biomolecular Mechanisms of Disease by cryo-EM
We are experts in a revolutionizing imaging technology known as cryo-electron microscopy (cryo-EM), which we use to illuminate the 3D-structures of biological macromolecules and characterize their functional and disease-state mechanisms with atomic-level detail.
Membrane Channels and Cell-Signaling Complexes
We study the mechanisms of membrane channel gating and cell-signaling events that orchestrate a wide range of physiological processes - from coordinating the rhythm of our heartbeat, to providing our senses to the world around us. We aim to understand these processes and their misregulation found in disease.
Another focus of our research is to understand how proteins are affected by aging and become associated with disease (e.g. arrhythmia, Alzheimer’s, cancer and vision loss). We’re experts in molecular aging mechanisms involved in cataract formation - the leading cause of blindness worldwide.
Protein Folding, Aging & Cataracts
We are always looking forward to beginning new collaborative relationships with investigators interested in biomolecular mechanism and cryo-EM. To discuss ideas and opportunities for collaboration with our lab contact Steve Reichow.